ATR signaling at a glance
نویسندگان
چکیده
منابع مشابه
ATR signaling at a glance.
The maintenance of genomic integrity is crucial for the survival of all organisms. In humans, compromised genomic integrity contributes to genetic disorders, aging and cancers. The task of safeguarding the genome is accomplished by the concerted action of a number of cellular processes, including DNA replication, DNA repair, senescence and apoptosis. Many, if not all, of these processes are reg...
متن کاملATM and ATR signaling at a glance.
ATM and ATR signaling pathways are well conserved throughout evolution and are central to the maintenance of genome integrity. Although the role of both ATM and ATR in DNA repair, cell cycle regulation and apoptosis have been well studied, both still remain in the focus of current research activities owing to their role in cancer. Recent advances in the field suggest that these proteins have an...
متن کاملCELL SCIENCE AT A GLANCE ATM and ATR signaling at a glance
ATM and ATR signaling pathways are well conserved throughout evolution and are central to the maintenance of genome integrity. Although the role of both ATM and ATR in DNA repair, cell cycle regulation and apoptosis have been well studied, both still remain in the focus of current research activities owing to their role in cancer. Recent advances in the field suggest that these proteins have an...
متن کاملNotch signaling at a glance.
Cell-cell interactions define a quintessential aspect of multicellular development. Metazoan morphogenesis depends on a handful of fundamental, conserved cellular interaction mechanisms, one of which is defined by the Notch signaling pathway. Signals transmitted through the Notch surface receptor have a unique developmental role: Notch signaling links the fate of one cell with that of a cellula...
متن کاملmTOR signaling at a glance.
glance Mathieu Laplante1,2 and David M. Sabatini1,2,3,* 1Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA 2Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA 3Koch Center for Integrative Cancer Research at MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA *Author for corresponde...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2009
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.035105